![]() The scientific community could now grow the PRIME-MRM resource with other cases and larger samples to further assess and increase the evidence base on the benefits of MRI monitoring of primates, complementing the animals’ clinical monitoring and treatment regime. We found that MRI assists in precise and early diagnosis of cerebral events and can be useful for visualising, treating and quantifying treatment response. For each case, we show MRI quantification of internal controls in relation to treatment steps and comparisons with normative data in typical monkeys drawn from PRIME-DE. Therefore, they were identified as suitable candidates for clinical investigation, MRI-based monitoring and treatment. In the cases, the monkeys presented with no or mild/moderate clinical signs, were well otherwise and MRI scanning did not present a significant increase in welfare impact. We also establish a PRIMatE MRI Monitoring (PRIME-MRM) resource within the PRIMatE Data Exchange (PRIME-DE) and quantitatively compare the cases to normative information drawn from MRI data from typical macaques in PRIME-DE. Here we show the utility and potential benefits of MRI-based monitoring in a few diverse cases with macaque monkeys. However, MRI monitoring is not established in macaques and a resource is urgently needed that could grow with scientific community contributions. MRI monitoring might also prove useful for non-human animals involved in neuroscience research provided that MRI is available and feasible and that there are no MRI contra-indications precluding scanning. Information from Magnetic Resonance Imaging (MRI) is useful for diagnosis and treatment management of human neurological patients. Some clinical situations, however, may be challenging and a multidisciplinary approach in the care of multiple sclerosis is warranted. This comparison has not been documented and may be helpful to overcome such difficulties.īased on clinical history and some strategies of ophthalmologic examination, physicians can achieve the correct diagnosis. However, other nondemyelinating visual disturbances also seen in the general population may be erroneously interpreted as being part of the underlying disease. Optic neuritis is representative of the most common and best-studied demyelinating visual occurrence in multiple sclerosis. The present article highlights nondemyelinating ocular occurrences due to physiologic or other pathologic processes that may appear in some patients. Multiple sclerosis may affect both afferent and efferent visual pathways, and sometimes physicians err on ordinary ophthalmologic diagnosis due to overlapping symptoms between demyelinating and nondemyelinating visual diseases. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
March 2023
Categories |